Polynucleotides

Polynucleotides are chains of purified DNA fragments, often called PDRN. Once injected into the skin, they are absorbed by your cells and signal them to produce more collagen and elastin, the proteins responsible for firmness and elasticity. They also support DNA repair and cellular metabolism, which together help the skin regenerate and renew. The effect is gradual: rather than filling a line, polynucleotides improve the quality and resilience of the skin itself over the weeks that follow.

After a face-to-face consultation and assessment, your nurse cleanses the area and injects the polynucleotide gel using a fine needle. A session usually takes 30 to 60 minutes. Small superficial lumps and some localised redness are normal immediately afterwards and typically settle within a few hours to a couple of days. We recommend avoiding sweating, heavy exercise and harsh skincare for a few days so the product can absorb fully.

Polynucleotides are valued for improving skin texture, elasticity and hydration, and for supporting tired, crepey or dehydrated skin. They can be used on the full face, under the eyes, the neck and décolletage, and the backs of the hands. Because they work by supporting your own skin biology, they suit a wide range of skin types and are a gentle alternative when volume or muscle-relaxing treatments are not what your skin needs.

Our clinic sits inside UNTIL Soho at 111 Charing Cross Road, around five minutes' walk from Tottenham Court Road and Leicester Square stations. Every polynucleotide treatment begins with a face-to-face consultation with one of our NMC-registered nurses, who will assess your skin, discuss your goals and confirm whether polynucleotides, or another regenerative option, will serve you best.