Polynucleotides

Polynucleotides are chains of purified DNA fragments, often called PDRN. Once injected into the skin, they are absorbed by your cells and signal them to produce more collagen and elastin, the proteins responsible for firmness and elasticity.

They also support cellular metabolism, helping the skin regenerate and renew. The effect is gradual: rather than filling a line, polynucleotides improve the quality and resilience of the skin itself over the weeks that follow.

After a face-to-face consultation and assessment, your nurse cleanses the area and injects the polynucleotide gel using a fine needle. A session usually takes 30 to 60 minutes. Small superficial lumps and some localised redness are normal immediately afterwards and typically settle within a few hours to a couple of days. We recommend avoiding sweating, heavy exercise and harsh skincare for a few days so the product can absorb fully.

All three are injected, but they do different jobs. Dermal fillers add volume and structure, sitting in the tissue to support shape. Skin boosters deliver hydration directly into the skin, improving radiance and softness fairly quickly. Polynucleotides work more slowly and more deeply: rather than adding anything, they encourage your skin to renew itself, which is why the change is in skin quality rather than shape.

They are often used together. At your consultation your nurse will explain which of the three, or which combination, suits what you actually want to change.

Polynucleotides are valued for improving skin texture, elasticity and hydration, and for supporting tired, crepey or dehydrated skin. They can be used on the full face, under the eyes, the neck and décolletage, and the backs of the hands. They suit a wide range of skin types and are a gentle option when volume or muscle-relaxing treatments are not what your skin needs.

Our clinic sits inside UNTIL Soho at 111 Charing Cross Road, around five minutes' walk from Tottenham Court Road and Leicester Square stations. Every polynucleotide treatment begins with a face-to-face consultation with one of our Aesthetic Nurse Practitioners, who will assess your skin, discuss your goals and confirm whether polynucleotides, or another regenerative option, will serve you best.